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. 2017 Nov 19;9(1):106–118. doi: 10.1002/jcsm.12250

Figure 4.

Figure 4

Trimetazidine improved the exercise intolerance induced by simvastatin in ApoE−/− mice. ApoE−/− mice were assigned to four groups: exercise, exercise + simvastatin (SMV), exercise + trimetazidine (TMZ), and exercise + SMV + TMZ. (A) Plasma concentrations of glucose and lipid. (B) Plasma concentrations of creatine kinase (CK). (C) Time of hanging grid test, forelimb grip strength, running time, and running distance are presented. N = 6. * P < 0.05 and ** P < 0.01 vs. exercise; # P < 0.05 and ## P < 0.01 vs. exercise + SMV; † P < 0.05 vs. exercise + TMZ. NEFA, non‐esterified fatty acid.