Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 19;9(1):106–118. doi: 10.1002/jcsm.12250

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Trimetazidine counteracted ragged red fibres and glycogen storage induced by simvastatin in ApoE^−/− mice. ApoE^−/− mice were assigned to four groups: exercise, exercise + simvastatin (SMV), exercise + trimetazidine (TMZ), and exercise + SMV + TMZ. Representative images of gastrocnemius sections are shown. (A) Representative images of Gomori staining and histogram of percentage for ragged red fibres (RRF). The black arrows indicate examples of RRF. (B) Representative images of PAS staining and histogram of optical density (OD). (C) Plasma concentration of lactic acid. N = 6. ^* P < 0.05 and ^*** P < 0.001 vs. exercise; ^# P < 0.05 and ^## P < 0.01 vs. exercise + SMV. Scale bar: 20 μm.