Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 19;9(1):106–118. doi: 10.1002/jcsm.12250

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Trimetazidine reversed statin‐induced mitochondrial dysfunction via modulation of mitochondrial complex III activity and oxidative stress. (A) Enzymatic activity of the complex III in mitochondria isolated from gastrocnemius. The activity of complex III is expressed in nmol reduced cytochrome c per mg mitochondrial protein. (B) Fluorescence of JC‐1 for mitochondria isolated from gastrocnemius. (C) Enzymatic activity of the citrate synthase (CS) in mitochondria isolated from gastrocnemius. The activity of CS is expressed in nmol 2‐nitro‐5‐thiobenzoate (TNB) per mg mitochondrial protein. (D) Fluorescence of Amplex Red oxidation for mitochondria isolated from gastrocnemius. (E) The activity of superoxide dismutase (SOD) in gastrocnemius. (F) The glutathione redox state (GSH/GSSG) in gastrocnemius. N = 6. ^* P < 0.05 vs. sedentary; ^# P < 0.05 and ^## P < 0.01 vs. exercise; ^† P < 0.05 vs. exercise + SMV.