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. 2017 Dec 22;9(1):129–145. doi: 10.1002/jcsm.12249

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© 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Telethonin is degraded in presence of MuRF1 and its E2 partners (A) telethonin level is depressed in HEK293 cells co‐transfected with MuRF1, telethonin and an E2 interacting with MuRF1 but not with the negative control E2D2. Immunoblotting was performed on cell lysates against telethonin. IB, immunoblot; Load: membranes were stained using Blot‐FastStain dye (a portion of the membrane is shown). (B) Densitometric analysis was used to correct for uneven loading. *P < 0.05, n = 6; **P < 0.01, n = 6.