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. 2017 Apr 22;96(5):939–947. doi: 10.1093/biolre/iox033

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© The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Two models for the role of CBs in long 3΄ UTR-mediated NMD in spermatids. (A) The Long 3΄ UTR NMD in Cytoplasm model. UPF1, UPF2, and UPF3B are sequestered and inactive in the CB. Cytoplasmic UPF3A interferes with UPF2, turning off EJC-stimulated NMD in these cells. Long 3΄ UTR-mediated NMD occurs in the cytoplasm by normal mechanisms. (B) The Long 3΄ UTR NMD in CBs model. UPF1, UPF2, and UPF3B are localized in the CB, but remain active. Messenger RNAs with long 3΄ UTRs are identified translationally and marked for transport to the CB, possibly by TDRD6. Nonsense-mediated mRNA decay occurs in the CB.