Table 1.
Pharmacokinetic parameter values used in the simulations
| Parameter | Mean estimate (90% CI or ±SD) | IIV | Uncertainty (variance)a | Reference |
|---|---|---|---|---|
| CL (L/h)b | 5.808 (3.792–7.80) | 0.238 | 1.4841 | Kjellsson et al.25 |
| Vc (L) | 10.1 (5.36–14.8) | 0.238*1.64 | 8.2329 | Kjellsson et al.25 |
| Vp (L) | 9.80 (5.70–13.9) | 0.197 | 6.2120 | Kjellsson et al.25 |
| Q (L/h)b | 15.36 (9.12–21.6) | NI | 14.3892 | Kjellsson et al.25 |
| COVCLCR‐CL | 0.0141 | – | – | |
| k10 (h−1) | 1.24 ± 0.55 | ND | 0.3025 | Segre et al.24 |
| k12 (h−1) | 1.69 ± 0.62 | ND | 0.3844 | Segre et al.24 |
| k23 (h−1) | 0.34 ± 0.10 | ND | 0.0100 | Segre et al.24 |
| kb (h−1) | 0.50 ± 0.18 | ND | 0.0324 | Segre et al.24 |
CL, clearance; Vc, volume of distribution of central compartment; Vp, volume of distribution of peripheral compartment; Q, intercompartmental clearance; COVCLCR‐CL , linear relationship between creatinine clearance and CL; k x,y, rate constants from compartment x to y; NI, not identified; kb, rate constant biliary elimination; ND, no data available.
a
Calculated from the 90% CI or SD.
b
Value converted to match units.