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. 2018 Feb 7;37:21. doi: 10.1186/s13046-018-0695-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Line map of the potential mechanisms that FL3 inhibits UCB cell cycle progression and cells proliferation. FL3 blocks the interaction of Akt and PHB, which in turn inhibits the process of PHB phosphorylation by Akt and decreases the PHB localization within mitochondria, leading to inhibition of UCB cell proliferation. Meanwhile, FL3 treatment attenuates the control of PHB to GADD45α, which consequently activates the GADD45α-dependent cell cycle arrest in the G2/M. Taken together, FL3 inhibits the UCB cell proliferation