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. 2018 Feb 5;13:791–804. doi: 10.2147/IJN.S152698

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© 2018 Sun et al. This work is published and licensed by Dove Medical Press Limited

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Evaluation of bone regeneration in calvarial defects of ovariectomized rats.

Notes: (A) Representative micro-CT images of calvarial defects treated with SIS, mSIS, and mSIS/P28 membranes. (B and C) BV/TV and BMD in the cranial defect implanted with those membranes. (D) Representative H&E staining images of SIS, mSIS, and mSIS/P28 groups at 8 weeks postsurgery. (F) High magnification images of the black rectangles in D (i, SIS; ii, mSIS; and iii, mSIS/P28). The osteoblast and new bone are indicated by the abbreviations “OB” and “NB”, respectively. (E) Histomorphometry analysis of percentage of new bone area in the rat cranial defect. Statistical significance is indicated by *p<0.05 compared to pure SIS group and ^#p<0.05 compared to mSIS group.

Abbreviations: BMD, bone mineral density; BV, bone volume; micro-CT, micro-computed tomography; mSIS, mineralized SIS; SIS, small intestinal submucosa; TV, tissue volume.