Table S2.

Univariate and multivariate analyses of prognostic factors associated with overall survival of patients with resected pancreatic head carcinoma in the validation cohort

Variables	Overall survival
	No. of patients (N = 1684)	Univariate (P-value)	Multivariate (P-value)	Hazard ratio (95% CI)
Age (years)		<0.001	<0.001	1.338 (1.184–1.511)
<70	1031
≥70	653
Gender		0.257
Male	869
Female	815
Grade		<0.001	<0.001	1.408 (1.279–1.550)
Well differentiation	182
Moderate differentiation	888
Poor differentiation	614
Liver metastasis		0.001	0.987	1.005 (0.585–1.724)
Yes	34
No	1650
Lung metastasis		0.024	0.800	0.904 (0.416–1.967)
Yes	9
No	1675
LNR		<0.001	<0.001	1.478 (1.237–1.766)
≤0.092	762
>0.092	922
T classification		<0.001	0.001	1.161 (1.065–1.266)
T1	236
T2	873
T3	263
T4	312
N classification		<0.001	0.128	1.139 (0.963–1.348)
N0	473
N1	752
N2	459
M classification		<0.001	0.003	2.085 (1.274–3.412)
M0	1617
M1	67
TNM staging system		<0.001	0.942	0.994 (0.838–1.178)
I	335
II	624
III	658
IV	67
Regional lymph nodes surgery		0.817
None	31
1–3	56
≥4	1597
Surgery		0.150
PPPD	171
Whipple	1190
Total pancreatectomy	229
Extended PD	94

Abbreviations: LNR, lymph node ratio; PD, pancreatoduodenectomy; PPPD, pylorus preserving pancreatoduodenectomy; TNM, tumor, node, metastasis.