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Model of melanosome transport during dispersion and aggregation, redrawn from Tuma and Gelfand (1999).
Notes: (A) Long-range melanosome dispersion occurs via transport by kinesin along microtubules. After reaching the cellular periphery, melanosomes are transported along randomly oriented actin filaments by myosin motor proteins. (B) Melanosome aggregation occurs via microtubules but, in contrast to pigmentary dispersion, takes place with the aid of dynein molecular motors.
