Table 3. ROC AUC values from the leave one out cross validation ROC AUC for assessing TdeP risk only across all data-sets for all models considered.
Leave One Out Cross Validation ROC AUC | ||||
---|---|---|---|---|
Data-set | 3 ion-channels | hERG | ||
Bnet | ORD: ΔAPD90 | TT: ΔAPD90 | % Block IKr | |
Mirams et al. (2011) | 0.78 | 0.66 | 0.75 | 0.62 |
Kramer et al. (2013) | 0.86 | 0.80 | 0.84 | 0.68 |
Crumb Jr et al. (2016) | 0.68 | 0.61 | 0.62 | 0.57 |
7 ion-channels | ||||
Crumb Jr et al. (2016) | 0.77 | 0.63 | 0.59* |
Notes.
based on six ion-channels—INaL not modelled by TenTusscher et al. (TT); ΔAPD90: percentage change in APD90.