Table 2. Correlations between mismatch repair protein deficiency and clinicopathological characteristics (n = 797).
| Characteristics | Number | dMMR | MLH1/ PMS2 | MSH2/MSH6 | |||
|---|---|---|---|---|---|---|---|
| Defective (%) | P value | Defective (%) | P value | Defective (%) | P value | ||
| Gender | |||||||
| Male | 495 | 73 (14.75) | 0.662 | 52 (10.51) | 0.561 | 21 (4.24) | 0.853 |
| Female | 302 | 48 (15.89) | 36 (11.92) | 12 (3.97) | |||
| Age | |||||||
| <50 | 99 | 29 (29.29) | <0.001 | 23 (23.23) | <0.001 | 6 (6.06) | 0.284* |
| ≥50 | 698 | 92 (13.18) | 65 (9.31) | 27 (3.87) | |||
| Location | |||||||
| Right side colon | 173 | 61(35.26) | <0.001 | 43 (24.86) | <0.001 | 18 (10.4) | <0.001 |
| Left side colon | 185 | 25 (13.51) | 18 (9.73) | 7 (3.78) | |||
| Rectum | 439 | 35 (7.97) | 27 (6.15) | 8 (1.82) | |||
| Mucin production | |||||||
| With | 131 | 36 (27.48) | <0.001 | 25 (19.08) | <0.001 | 11 (8.4) | 0.007 |
| Without | 666 | 85 (12.76) | 63 (9.46) | 22 (3.3) | |||
| Tumor differentiation | |||||||
| Poor | 134 | 36 (26.87) | <0.001 | 24 (17.91) | <0.001 | 12 (8.96) | 0.012* |
| Moderate | 589 | 71 (12.05) | 51(8.66) | 20 (3.39) | |||
| Well | 31 | 4 (12.9) | 3 (9.68) | 1 (3.23) | |||
| Unknown | 43 | ||||||
| Tumor stage | |||||||
| I | 94 | 6 (6.38) | 0.019 | 5 (5.32) | 0.110 | 1 (1.06) | 0.288* |
| II | 326 | 62 (19.02) | 45 (13.81) | 17 (5.21) | |||
| III | 301 | 41 (13.62) | 30 (9.97) | 11 (3.65) | |||
| IV | 76 | 12 (15.79) | 8 (10.52) | 4 (5.26) | |||
| Bowel wall invasion (T) | |||||||
| T1 | 20 | 3 (15) | 0.018 | 2 (10) | 0.139 | 1 (5) | 0.067* |
| T2 | 102 | 5 (4.9) | 5 (4.9) | 0 (0) | |||
| T3 | 334 | 59 (17.66) | 44 (13.17) | 15 (4.49) | |||
| T4 | 341 | 54 (15.83) | 37 (10.85) | 17 (4.98) | |||
| Lymph node metastasis (N) | |||||||
| N0 | 445 | 74 (16.63) | 0.192 | 54 (12.13) | 0.354 | 20 (4.49) | 0.583 |
| N1 | 200 | 31 (15.5) | 22 (11) | 9 (4.5) | |||
| N2 | 152 | 16 (10.53) | 12 (7.89) | 4 (2.63) | |||
| Distant metastasis (M) | |||||||
| M0 | 721 | 110 (15.26) | 0.550 | 80 (12.13) | 0.88 | 30 (4.16) | 0.929* |
| M1 | 76 | 11 (14.47) | 8 (10.53) | 3 (3.95) | |||
| Lymphovascular invasion | |||||||
| Yes | 335 | 47 (14.03) | 0.451 | 35 (10.45) | 0.679 | 12 (3.58) | 0.481 |
| No | 457 | 73 (15.97) | 52 (11.38) | 21 (4.59) | |||
| Unknown | 5 | ||||||
| Alcohol intake | |||||||
| Ever | 162 | 19 (11.72) | 0.170 | 13 (8.02) | 0.170 | 6 (3.7) | 0.755 |
| Never | 635 | 102 (16.06) | 75 (11.81) | 27 (4.25) | |||
| Smoking | |||||||
| Ever | 263 | 35 (13.31) | 0.170 | 24 (9.13) | 0.226 | 11 (4.18) | 0.967 |
| Never | 534 | 86 (16.1) | 64 (11.98) | 22 (4.12) | |||
| Colorectal family history | |||||||
| Yes | 48 | 11 (22.92) | 0.071 | 5 (10.42) | 0.795 | 6 (12.5) | 0.016* |
| No | 335 | 44 (13.13) | 32 (9.55) | 12 (3.58) | |||
| Unknown | 414 | ||||||
Notes.
*
Fisher’s exact test was used.