Table 3. Correlations between RAS gene mutations and clinicopathological characteristics (n = 813).
| Characteristics | Number | RAS | KRAS | NRAS | |||
|---|---|---|---|---|---|---|---|
| Mutation (%) | P value | Mutation (%) | P value | Mutation (%) | P value | ||
| Gender | |||||||
| Male | 506 | 221 (43.68) | 0.105 | 204 (40.32) | 0.097 | 19 (3.75) | 0.9 |
| Female | 307 | 152 (49.51) | 142 (46.25) | 11 (3.58) | |||
| Age | |||||||
| <50 | 100 | 38 (38) | 0.091 | 37 (37) | 0.23 | 1 (1) | 0.161* |
| ≥50 | 713 | 335 (46.98) | 309 (43.34) | 29 (4.07) | |||
| Location | |||||||
| Right side colon | 181 | 91 (50.28) | 0.178 | 88 (48.62) | 0.097 | 3 (1.66) | 0.164 |
| Left side colon | 189 | 77 (40.74) | 71 (37.57) | 6 (3.17) | |||
| Rectum | 443 | 205 (46.28) | 187 (42.21) | 21 (4.74) | |||
| Mucin production | |||||||
| With | 133 | 74 (55.64) | 0.014 | 73 (54.89) | 0.002 | 1 (0.75) | 0.087 |
| Without | 680 | 299 (43.97) | 273 (40.18) | 29 (4.22) | |||
| Tumor differentiation | |||||||
| Poor | 138 | 55 (39.86) | 0.315 | 54 (39.13) | 0.604 | 1 (0.72) | 0.093 |
| Moderate | 599 | 276 (46.08) | 251 (41.9) | 28 (4.67) | |||
| Well | 33 | 17 (51.52) | 16 (48.48) | 1 (3.03) | |||
| Unknown | 43 | ||||||
| Tumor stage | |||||||
| I | 95 | 41 (43.16) | 0.031 | 35 (36.84) | 0.023 | 6 (6.32) | 0.18* |
| II | 332 | 170 (51.2) | 161 (48.49) | 9 (2.71) | |||
| III | 302 | 133 (44.04) | 122 (40.4) | 14 (4.64) | |||
| IV | 84 | 29 (34.52) | 28 (34.52) | 1 (1.19) | |||
| Bowel wall invasion (T) | |||||||
| T1 | 21 | 9 (42.86) | 0.36 | 8 (38.1) | 0.158 | 1 (4.76) | 0.36* |
| T2 | 104 | 40 (38.46) | 34 (32.69) | 6 (5.77) | |||
| T3 | 336 | 154 (45.83) | 146 (43.45) | 9 (2.68) | |||
| T4 | 352 | 170 (48.3) | 158 (44.89) | 14 (3.98) | |||
| Lymph node metastasis (N) | |||||||
| N0 | 458 | 224 (48.91) | 0.006 | 209 (45.63) | 0.079 | 15 (3.28) | 0.265 |
| N1 | 203 | 88 (43.35) | 83 (40.89) | 6 (2.96) | |||
| N2 | 152 | 61 (40.13) | 54 (35.53) | 9 (5.92) | |||
| Distant metastasis (M) | |||||||
| M0 | 729 | 343 (47.05) | 0.048 | 317 (43.48) | 0.116 | 29 (3.98) | 0.353* |
| M1 | 84 | 30 (35.71) | 29 (34.52) | 1 (1.19) | |||
| Lymphovascular invasion | |||||||
| Yes | 339 | 157 (46.31) | 0.763 | 145 (42.77) | 0.825 | 14 (4.13) | 0.623 |
| No | 462 | 209 (45.24) | 194 (41.99) | 16 (3.46) | |||
| Unknown | 12 | ||||||
| Alcohol intake | |||||||
| Ever | 165 | 67 (40.61) | 0.128 | 63 (38.18) | 0.203 | 5 (3.03) | 0.615 |
| Never | 648 | 306 (47.22) | 283 (43.67) | 25 (3.86) | |||
| Smoking | |||||||
| Ever | 283 | 109 (38.52) | 0.002 | 99 (34.98) | 0.001 | 10 (3.53) | 0.863 |
| Never | 530 | 264 (49.81) | 247 (46.6) | 20 (3.77) | |||
| Colorectal family history | |||||||
| Yes | 48 | 28 (58.33) | 0.017 | 26 (54.17) | 0.013 | 3 (6.25) | 0.178* |
| No | 337 | 135 (40.95) | 126 (37.39) | 9 (2.67) | |||
| Unknown | 428 | ||||||
Notes.
*
Fisher’s exact test was used.