Table 5. Correlations between KRAS gene mutations and clinicopathological characteristics in dMMR tumors (n = 121).
| Characteristics | Number | KRAS | P value |
|---|---|---|---|
| Mutation (%) | |||
| Gender | |||
| Male | 73 | 31 (42.47) | 0.555 |
| Female | 48 | 23 (47.91) | |
| Age | |||
| <50 | 29 | 11 (37.93) | 0.405 |
| ≥50 | 92 | 43 (46.74) | |
| Location | |||
| Right side colon | 61 | 26 (42.62) | 0.891 |
| Left side colon | 25 | 12 (48) | |
| Rectum | 35 | 16 (45.71) | |
| Mucin production | |||
| With | 36 | 20 (55.56) | 0.116 |
| Without | 85 | 34 (40) | |
| Tumor differentiation | |||
| Poor | 36 | 10 (27.78) | 0.099* |
| Moderate | 71 | 35 (49.3) | |
| Well | 4 | 2 (50) | |
| Unknown | 10 | ||
| Tumor stage | |||
| I | 6 | 2 (33.33) | 0.277* |
| II | 62 | 33 (53.2) | |
| III | 41 | 15 (36.59) | |
| IV | 12 | 4 (33.33) | |
| Bowel wall invasion (T) | |||
| T1 | 3 | 2 (66.67) | 0.179* |
| T2 | 5 | 0 (0) | |
| T3 | 59 | 26 (44.07) | |
| T4 | 54 | 26 (48.15) | |
| Lymph node metastasis (N) | |||
| N0 | 74 | 38 (51.35) | 0.056 |
| N1 | 31 | 13 (41.94) | |
| N2 | 16 | 3 (18.75) | |
| Distant metastasis (M) | |||
| M0 | 110 | 50 (45.45) | 0.753* |
| M1 | 11 | 4 (36.36) | |
| Lymphovascular invasion | |||
| Yes | 47 | 21 (44.68) | 0.927 |
| No | 73 | 32 (43.83) | |
| Unknown | 1 | ||
| Alcohol intake | |||
| Ever | 19 | 9 (47.37) | 0.855 |
| Never | 102 | 46 (45.1) | |
| Smoking | |||
| Ever | 35 | 14 (40) | 0.514 |
| Never | 86 | 40 (46.51) | |
| Colorectal family history | |||
| Yes | 11 | 5 (45.45) | 0.589 |
| No | 44 | 24 (54.55) | |
| Unknown | 66 |
Notes.
*
Fisher’s exact test was used.