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. 2017 Dec 31;2017:2904150. doi: 10.1155/2017/2904150

Figure 6.

Figure 6

Effects of UPARANT on Evans blue leakage. (a–d) Blood-retinal vascular leakage as qualitatively evaluated with the Evans blue method in control SD (a) and SDT rats untreated (b), vehicle-treated (c), or UPARANT-treated (d). Arrows in (c) and (d) point to vascular leakage. Scale bar: 200 μm. (e) Diabetes-induced leakage as evaluated by the quantitative assessment of Evans blue dye extravasation. In untreated or vehicle-treated SDT rats, Evans blue dye leakage was increased with respect to SD rats, while UPARANT treatment prevented this increase. ∗P < 0.001 versus control; §P < 0.001 versus vehicle (one-way ANOVA followed by Newman–Keuls' multiple comparison posttest; power value: 0.84). Each column represents the mean ± SEM of data from 3 retinas from 3 different rats for each experimental condition. Three retinas from 3 different rats were used for each experimental condition.