Table 2.
Cox proportional hazard univariate regression analysis of miR-155-5p expression and clinicopathological variables for the prediction of CLL patients' OS.
| Covariate | HR | 95% CI | p value | BCa bootstrap (95% CI) | Bootstrap (p value) |
|---|---|---|---|---|---|
| miR-155-5p expression | 1.80 | 1.19–2.72 | 0.006 | 1.08–3.00 | 0.007 |
| miR-155-5p expression status | |||||
| Negative | 1.00 | ||||
| Positive | 3.87 | 1.70–8.81 | 0.001 | 1.76–11.72 | <0.001 |
| Age | 0.98 | 0.94–1.02 | 0.33 | 0.93–1.02 | 0.36 |
| Binet stage (ordinal) | 1.98 | 1.3–3.02 | 0.002 | 1.38–2.97 | <0.001 |
| Rai stage (ordinal) | 1.50 | 1.14–1.98 | 0.004 | 1.16–2.02 | 0.002 |
| Risk (ordinal) | 3.01 | 1.52–5.94 | 0.002 | 1.85–5.29 | <0.001 |
| Serum LDH concentration | |||||
| Normal | 1.00 | ||||
| Elevated | 1.61 | 0.76–3.41 | 0.22 | 0.74–3.66 | 0.21 |
| CD38 expression status | |||||
| Negative | 1.00 | ||||
| Positive | 3.57 | 1.68–7.58 | <0.001 | 1.46–13.11 | <0.001 |
| IGHV mutational status | |||||
| Mutated | 1.00 | ||||
| Unmutated | 2.78 | 1.18–6.55 | 0.020 | 1.19–7.99 | 0.013 |
CLL: chronic lymphocytic leukemia; OS: overall survival; HR: hazard ratio; CI: confidence interval; BCa: bias-corrected and accelerated; LDH: lactate dehydrogenase; IGHV: immunoglobulin heavy chain variable region.