Table 2.

Ex vivo biodistribution (% ID/g) of ⁶⁸Ga-DOTA-Siglec-9 and ¹⁸F-FDR-Siglec-9 at 60 min after injection in rats with skin/muscle inflammation.

Organ	68Ga-DOTA-Siglec-9	18F-FDR-Siglec-9	P  value∗
Control area	0.051 ± 0.0063	0.11 ± 0.056	0.015
Inflamed area	0.12 ± 0.032	0.19 ± 0.053	0.013
Adipose tissue, BAT	0.024 ± 0.026	0.049 ± 0.019	0.12
Adipose tissue, WAT	0.027 ± 0.014	0.017 ± 0.0041	0.090
Blood	0.099 ± 0.040	0.12 ± 0.023	0.33
Bone (femoral)	0.020 ± 0.0089	0.017 ± 0.010	0.67
Bone marrow	0.039 ± 0.012	0.056 ± 0.011	0.022
Brain	0.0062 ± 0.0049	0.010 ± 0.0030	0.083
Heart	0.030 ± 0.011	0.048 ± 0.010	0.0038
Kidneys	2.8 ± 1.8	14 ± 9.9	0.0053
Liver	0.32 ± 0.16	0.68 ± 0.12	0.00014
Lungs	0.079 ± 0.035	0.11 ± 0.028	0.059
Muscle	0.019 ± 0.0091	0.021 ± 0.0067	0.68
Pancreas	0.024 ± 0.0024	0.048 ± 0.011	0.00062
Plasma	0.13 ± 0.015	0.23 ± 0.087	0.087
Small intestine	0.060 ± 0.016	0.091 ± 0.029	0.051
Spleen	0.19 ± 0.110	0.060 ± 0.012	0.0048
Testis	0.035 ± 0.031	0.046 ± 0.022	0.45
Urine	24 ± 11	23 ± 14	0.93

% ID/g = percentage of injected radioactivity dose per gram of tissue; BAT=brown adipose tissue; WAT = white adipose tissue. ^∗Unpaired, 2-tailed Student's t-test.