Table 4.

Human dose equivalent estimates (mSv/MBq) extrapolated from the rat PET data.

Organ	68Ga-DOTA-Siglec-9	18F-FDR- Siglec-9	P  value∗
Adrenals	0.014 ± 0.0012	0.020 ± 0.0029	0.0011
Brain	0.012 ± 0.00077	0.010 ± 0.0018	0.064
Breasts	0.011 ± 0.00064	0.0086 ± 0.0011	0.0036
Gallbladder wall	0.014 ± 0.00065	0.017 ± 0.0014	0.00022
Heart wall	0.0083 ± 0.0010	0.0085 ± 0.00045	0.52
Kidneys	0.15 ± 0.12	0.29 ± 0.13	0.070
Liver	0.012 ± 0.0024	0.021 ± 0.0061	0.014
Lower large intestine wall	0.015 ± 0.00077	0.014 ± 0.00091	0.067
Lungs	0.0044 ± 0.00054	0.0062 ± 0.00016	<0.0001
Muscle	0.0050 ± 0.00018	0.0074 ± 0.00025	<0.0001
Ovaries	0.015 ± 0.00064	0.014 ± 0.00083	0.14
Pancreas	0.014 ± 0.00085	0.018 ± 0.0015	0.00018
Red marrow	0.010 ± 0.00037	0.012 ± 0.00032	<0.0001
Osteogenic cells	0.017 ± 0.00094	0.016 ± 0.0019	0.43
Skin	0.010 ± 0.00054	0.0080 ± 0.00080	0.00019
Small intestine	0.014 ± 0.00047	0.015 ± 0.00049	0.0034
Spleen	0.014 ± 0.0011	0.018 ± 0.0022	0.00074
Stomach wall	0.013 ± 0.00065	0.014 ± 0.00041	0.0057
Testes	0.013 ± 0.00062	0.010 ± 0.0010	0.0012
Thymus	0.011 ± 0.00068	0.010 ± 0.0013	0.014
Thyroid	0.011 ± 0.00072	0.0094 ± 0.0014	0.017
Upper large intestine wall	0.014 ± 0.00046	0.015 ± 0.00045	0.0036
Urinary bladder wall	0.20 ± 0.087	0.081 ± 0.032	0.0037
Uterus	0.018 ± 0.0017	0.017 ± 0.0012	0.31
Total body	0.013 ± 0.00041	0.012 ± 0.00012	0.00073
Effective dose	0.024 ± 0.0041	0.022 ± 0.0042	0.58

^∗Unpaired, 2-tailed Student's t-test.