Figure 2:

Epigenetic misregulation in congenital epigenetic disorders and acquired epigenetic disorders. ( A ) Abnormalities in a methylated CpG binding protein or a DNA methyltransferase result in Rett syndrome or ICF syndrome, respectively. An aberrant genomic pattern due to failure of genomic imprinting results in Prader-Willi syndrome. ( B ) Environmental factors alter epigenomic status, resulting in predispositions to various common disorders