Figure 5.

Changes in DNA methylation profiles after hybridization of Xenopus frogs. The graph shows methylated (blue) and unmethylated (red) fragments obtained by MS-AFLP from muscle tissue of parents and their F1 hybrids. Hybrids have higher proportions of methylated fragments than the parental species. Seventy-six methylated fragments are diagnostic of hybrids only suggesting the involvement of DNA methylation in genome reconfiguration after hybridization. Some of the methylated fragments in hybrids are sex-specific and may account for the difference in fertility between females and males (redrawn after [85]; photograph of X. laevis by Benedikt Rauscher, photograph of X. muelleri by Martin Grimm)