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. 2015 Nov 27;1(1):dvv007. doi: 10.1093/eep/dvv007

Table 2.

differentially methylated positions in cord blood in relation to quartiles of maternal urinary lead concentrations in early gestation

CpG Chr. Positiona Gene Gene names β b 95% CI lower 95% CI higher q Betac
cg18355337 19 55549722 GP6 glycoprotein VI (platelet) –0.30 –0.42 –0.20 0.029 0.53
cg25196158 1 214152979 NAd (PROX1) (prospero homeobox 1) –0.14 –0.20 –0.09 0.029 0.09
cg16943697 2 120280763 SCTR secretin receptor –0.10 –0.14 –0.06 0.029 0.54
cg03833077 19 10024709 OLFM2 olfactomedin 2 –0.32 –0.45 –0.20 0.029 0.19
cg12504721 5 138897583 NA (TMEM173) (transmembrane protein 173) –0.10 –0.15 –0.07 0.031 0.04
cg23796967 19 55549590 GP6 glycoprotein VI (platelet) –0.18 –0.25 –0.10 0.041 0.72
cg00145875 2 11104394 NA (KCNF1) (potassium channel, voltage gated modifier subfamily F, member 1) –0.09 –0.12 –0.06 0.047 0.80
cg25818583 19 55549801 GP6 glycoprotein VI (platelet) –0.17 –0.23 –0.10 0.047 0.63
cg23173307 4 786244 CPLX1 complexin 1 –0.14 –0.20 –0.09 0.047 0.04
cg04942107 10 3918567 NA (KLF6) (kruppel-like factor 6) 0.07 0.04 0.08 0.057 0.87
cg05374025 19 55549746 GP6 glycoprotein VI (platelet) –0.23 –0.34 –0.15 0.057 0.44
cg26668675 6 31148463 NA (PSORS1C3) (psoriasis susceptibility 1 candidate 3) –0.17 –0.23 –0.10 0.062 0.44
cg25472897 8 145560555 SCRT1 scratch family zinc finger 1 –0.10 –0.15 –0.06 0.070 0.18
cg00436174 2 128051630 ERCC3 excision repair cross-complementation group 3 −0.07 −0.12 −0.04 0.081 0.10
cg11790196 14 89995679 FOXN3 forkhead box N3 −0.29 −0.40 −0.17 0.089 0.95

Chr, chromosome; q, FDR-adjusted P value; CI, confidence interval.

aPosition according to the Genome Reference Consortium GRCh37 [17].

b β denotes β1 in the following robust regression model: M value = β1 × quartile lead in urine + β2 × surrogate variable (from sva analysis).

cThe average methylation as Beta value for all individuals (ranging from 0 to 1, where 1 means fully methylated).

dNA, not applicable, i.e. the CpG is not present in any known gene, the gene name in brackets denotes the gene with the closest transcription start site.