Table 2.
differentially methylated positions in cord blood in relation to quartiles of maternal urinary lead concentrations in early gestation
| CpG | Chr. | Positiona | Gene | Gene names | β b | 95% CI lower | 95% CI higher | q | Betac |
|---|---|---|---|---|---|---|---|---|---|
| cg18355337 | 19 | 55549722 | GP6 | glycoprotein VI (platelet) | –0.30 | –0.42 | –0.20 | 0.029 | 0.53 |
| cg25196158 | 1 | 214152979 | NAd (PROX1) | (prospero homeobox 1) | –0.14 | –0.20 | –0.09 | 0.029 | 0.09 |
| cg16943697 | 2 | 120280763 | SCTR | secretin receptor | –0.10 | –0.14 | –0.06 | 0.029 | 0.54 |
| cg03833077 | 19 | 10024709 | OLFM2 | olfactomedin 2 | –0.32 | –0.45 | –0.20 | 0.029 | 0.19 |
| cg12504721 | 5 | 138897583 | NA (TMEM173) | (transmembrane protein 173) | –0.10 | –0.15 | –0.07 | 0.031 | 0.04 |
| cg23796967 | 19 | 55549590 | GP6 | glycoprotein VI (platelet) | –0.18 | –0.25 | –0.10 | 0.041 | 0.72 |
| cg00145875 | 2 | 11104394 | NA (KCNF1) | (potassium channel, voltage gated modifier subfamily F, member 1) | –0.09 | –0.12 | –0.06 | 0.047 | 0.80 |
| cg25818583 | 19 | 55549801 | GP6 | glycoprotein VI (platelet) | –0.17 | –0.23 | –0.10 | 0.047 | 0.63 |
| cg23173307 | 4 | 786244 | CPLX1 | complexin 1 | –0.14 | –0.20 | –0.09 | 0.047 | 0.04 |
| cg04942107 | 10 | 3918567 | NA (KLF6) | (kruppel-like factor 6) | 0.07 | 0.04 | 0.08 | 0.057 | 0.87 |
| cg05374025 | 19 | 55549746 | GP6 | glycoprotein VI (platelet) | –0.23 | –0.34 | –0.15 | 0.057 | 0.44 |
| cg26668675 | 6 | 31148463 | NA (PSORS1C3) | (psoriasis susceptibility 1 candidate 3) | –0.17 | –0.23 | –0.10 | 0.062 | 0.44 |
| cg25472897 | 8 | 145560555 | SCRT1 | scratch family zinc finger 1 | –0.10 | –0.15 | –0.06 | 0.070 | 0.18 |
| cg00436174 | 2 | 128051630 | ERCC3 | excision repair cross-complementation group 3 | −0.07 | −0.12 | −0.04 | 0.081 | 0.10 |
| cg11790196 | 14 | 89995679 | FOXN3 | forkhead box N3 | −0.29 | −0.40 | −0.17 | 0.089 | 0.95 |
Chr, chromosome; q, FDR-adjusted P value; CI, confidence interval.
aPosition according to the Genome Reference Consortium GRCh37 [17].
b β denotes β1 in the following robust regression model: M value = β1 × quartile lead in urine + β2 × surrogate variable (from sva analysis).
cThe average methylation as Beta value for all individuals (ranging from 0 to 1, where 1 means fully methylated).
dNA, not applicable, i.e. the CpG is not present in any known gene, the gene name in brackets denotes the gene with the closest transcription start site.