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. 2015 Nov 27;1(1):dvv007. doi: 10.1093/eep/dvv007

Table 3.

differentially methylated positions in cord blood in relation to quartiles of maternal erythrocyte lead concentrations in early gestation

CpG Chr. Positiona Gene Gene names β b 95% CI lower 95% CI higher q Betac
cg01519017 3 61227050 FHIT fragile histidine triad −0.10 –0.13 –0.07 0.001 0.90
cg16653408 22 42313569 NAd (SHISA8) (shisa family member 8) –0.11 –0.15 –0.07 0.002 0.66
cg03978169 6 33091357 HLA-DPB2 HLA-DPB2 –0.12 –0.17 –0.08 0.052 0.90
cg18461584 7 55304314 NA (EGFR) (epidermal growth factor receptor) –0.13 –0.18 –0.08 0.089 0.92
cg23352003 18 24237245 NA (KCTD1) (potassium channel tetramerization domain containing 1) –0.29 –0.41 –0.18 0.13 0.03
cg07313720 2 209029594 CRYGA crystallin, gamma A 0.29 0.18 0.41 0.14 0.95
cg04432660 7 4802132 FOXK1 forkhead box K1 –0.12 –0.17 –0.07 0.19 0.94
cg04606773 10 134759693 NA (C4AP46) (cilia and flagella associated protein 46) –0.15 –0.21 −0.09 0.19 0.91
cg22994018 11 105448797 NA (GRIA4) (glutamate receptor, ionotropic, AMPA 4) 0.42 0.25 0.59 0.19 0.89
cg25979157 19 53902687 ZNF765 zinc finger protein 765 −0.09 −0.13 −0.05 0.19 0.92
cg11774346 21 46797899 NA (COL18A1) (collagen, type XVIII, alpha 1) −0.12 −0.17 −0.07 0.19 0.90
cg11668188 1 7891116 PER3 period circadian clock 3 0.45 0.26 0.64 0.19 0.96
cg25192902 11 121163419 SC5DL sterol-C5-desaturase −0.12 −0.17 −0.07 0.19 0.03
cg24737570 2 11727173 GREB1 growth regulation by estrogen in breast cancer 1 −0.07 −0.1 −0.04 0.19 0.82
cg05749559 8 36793457 KCNU1 potassium channel, subfamily U, member 1 −0.11 −0.16 −0.06 0.19 0.89

Chr, chromosome; q, FDR-adjusted P value; CI, confidence interval.

aPosition according to the Genome Reference Consortium GRCh37 [17].

b β denotes β1 in the following robust regression model: M value = β1 × quartile lead in erythrocytes + β2 × surrogate variable (from sva analysis).

cThe average methylation as Beta value for all individuals (ranging from 0 to 1, where 1 means fully methylated).

dNA, not applicable, i.e. the CpG is not present in any known gene, the gene name in brackets denotes the gene with the closest transcription start site.