Table 3.
differentially methylated positions in cord blood in relation to quartiles of maternal erythrocyte lead concentrations in early gestation
| CpG | Chr. | Positiona | Gene | Gene names | β b | 95% CI lower | 95% CI higher | q | Betac |
|---|---|---|---|---|---|---|---|---|---|
| cg01519017 | 3 | 61227050 | FHIT | fragile histidine triad | −0.10 | –0.13 | –0.07 | 0.001 | 0.90 |
| cg16653408 | 22 | 42313569 | NAd (SHISA8) | (shisa family member 8) | –0.11 | –0.15 | –0.07 | 0.002 | 0.66 |
| cg03978169 | 6 | 33091357 | HLA-DPB2 | HLA-DPB2 | –0.12 | –0.17 | –0.08 | 0.052 | 0.90 |
| cg18461584 | 7 | 55304314 | NA (EGFR) | (epidermal growth factor receptor) | –0.13 | –0.18 | –0.08 | 0.089 | 0.92 |
| cg23352003 | 18 | 24237245 | NA (KCTD1) | (potassium channel tetramerization domain containing 1) | –0.29 | –0.41 | –0.18 | 0.13 | 0.03 |
| cg07313720 | 2 | 209029594 | CRYGA | crystallin, gamma A | 0.29 | 0.18 | 0.41 | 0.14 | 0.95 |
| cg04432660 | 7 | 4802132 | FOXK1 | forkhead box K1 | –0.12 | –0.17 | –0.07 | 0.19 | 0.94 |
| cg04606773 | 10 | 134759693 | NA (C4AP46) | (cilia and flagella associated protein 46) | –0.15 | –0.21 | −0.09 | 0.19 | 0.91 |
| cg22994018 | 11 | 105448797 | NA (GRIA4) | (glutamate receptor, ionotropic, AMPA 4) | 0.42 | 0.25 | 0.59 | 0.19 | 0.89 |
| cg25979157 | 19 | 53902687 | ZNF765 | zinc finger protein 765 | −0.09 | −0.13 | −0.05 | 0.19 | 0.92 |
| cg11774346 | 21 | 46797899 | NA (COL18A1) | (collagen, type XVIII, alpha 1) | −0.12 | −0.17 | −0.07 | 0.19 | 0.90 |
| cg11668188 | 1 | 7891116 | PER3 | period circadian clock 3 | 0.45 | 0.26 | 0.64 | 0.19 | 0.96 |
| cg25192902 | 11 | 121163419 | SC5DL | sterol-C5-desaturase | −0.12 | −0.17 | −0.07 | 0.19 | 0.03 |
| cg24737570 | 2 | 11727173 | GREB1 | growth regulation by estrogen in breast cancer 1 | −0.07 | −0.1 | −0.04 | 0.19 | 0.82 |
| cg05749559 | 8 | 36793457 | KCNU1 | potassium channel, subfamily U, member 1 | −0.11 | −0.16 | −0.06 | 0.19 | 0.89 |
Chr, chromosome; q, FDR-adjusted P value; CI, confidence interval.
aPosition according to the Genome Reference Consortium GRCh37 [17].
b β denotes β1 in the following robust regression model: M value = β1 × quartile lead in erythrocytes + β2 × surrogate variable (from sva analysis).
cThe average methylation as Beta value for all individuals (ranging from 0 to 1, where 1 means fully methylated).
dNA, not applicable, i.e. the CpG is not present in any known gene, the gene name in brackets denotes the gene with the closest transcription start site.