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. 2015 Nov 27;1(1):dvv007. doi: 10.1093/eep/dvv007

Table 4.

DMRs in cord blood in relation to quartiles of maternal urinary lead concentrations in early gestation

Gene Gene names Chr. Starta Enda Directionb Areac Nr. CpGs P unadj. q
RNF39 ring finger protein 39 6 30038998 30039600 + 4.05 26 0.0004 0.40
NAd (PSORS1C3) (psoriasis susceptibility 1 candidate 3) 6 31148332 31148748 1.98 15 0.003 0.48
NFYA nuclear transcription factor Y, alpha 6 41068553 41068752 1.61 7 0.004 0.48
CRISP2 cysteine-rich secretory protein 2 6 49681178 49681391 1.43 7 0.005 0.48
GP6 glycoprotein VI (platelet) 19 55549414 55549842 1.42 8 0.005 0.48
PIWIL2 piwi-like RNA-mediated gene silencing 2 8 22132678 22133076 1.37 9 0.005 0.48
C5orf63 chromosome 5 open reading frame 63 5 126408756 126409372 1.34 11 0.005 0.48
TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) 1 75198211 75199117 1.29 11 0.006 0.48
NA (ZBED9) zinc finger, BED-type containing 9 6 (28601269 28601519) 1.22 13 0.006 0.48
KRTCAP3 keratinocyte associated protein 3 2 27665017 27665711 1.15 11 0.007 0.48
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 18 23713407 23714084 1.10 10 0.008 0.48
SLFN12 schlafen family member 12 17 33759512 33760293 1.06 10 0.009 0.48
PAX8 paired box 8 2 113992762 113992930 + 1.05 4 0.009 0.48
PXDNL peroxidasin-like 8 52321814 52322171 1.04 6 0.009 0.48
HCG4P6 HLA complex group 4B 6 29894619 29894820 1.03 6 0.009 0.48

Chr, chromosome; q, FDR-adjusted P value.

aPosition of start and end of the DMR according to Genome build 37 [17].

bDirection of association with urinary lead (as a continuous variable, divided into quartiles).

cThe strength of evidence for each DMR is summarized with its area [18].

dNA, not applicable, i.e. the CpG is not present in any known gene, the gene name in brackets denotes the gene with the closest transcription start site.