Table 4.

DMRs in cord blood in relation to quartiles of maternal urinary lead concentrations in early gestation

Gene	Gene names	Chr.	Starta	Enda	Directionb	Areac	Nr. CpGs	P unadj.	q
RNF39	ring finger protein 39	6	30038998	30039600	+	4.05	26	0.0004	0.40
NAd (PSORS1C3)	(psoriasis susceptibility 1 candidate 3)	6	31148332	31148748	–	1.98	15	0.003	0.48
NFYA	nuclear transcription factor Y, alpha	6	41068553	41068752	–	1.61	7	0.004	0.48
CRISP2	cysteine-rich secretory protein 2	6	49681178	49681391	–	1.43	7	0.005	0.48
GP6	glycoprotein VI (platelet)	19	55549414	55549842	–	1.42	8	0.005	0.48
PIWIL2	piwi-like RNA-mediated gene silencing 2	8	22132678	22133076	–	1.37	9	0.005	0.48
C5orf63	chromosome 5 open reading frame 63	5	126408756	126409372	–	1.34	11	0.005	0.48
TYW3	tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)	1	75198211	75199117	–	1.29	11	0.006	0.48
NA (ZBED9)	zinc finger, BED-type containing 9	6	(28601269	28601519)	–	1.22	13	0.006	0.48
KRTCAP3	keratinocyte associated protein 3	2	27665017	27665711	–	1.15	11	0.007	0.48
PSMA8	proteasome (prosome, macropain) subunit, alpha type, 8	18	23713407	23714084	–	1.10	10	0.008	0.48
SLFN12	schlafen family member 12	17	33759512	33760293	–	1.06	10	0.009	0.48
PAX8	paired box 8	2	113992762	113992930	+	1.05	4	0.009	0.48
PXDNL	peroxidasin-like	8	52321814	52322171	–	1.04	6	0.009	0.48
HCG4P6	HLA complex group 4B	6	29894619	29894820	–	1.03	6	0.009	0.48

Chr, chromosome; q, FDR-adjusted P value.

^aPosition of start and end of the DMR according to Genome build 37 [17].

^bDirection of association with urinary lead (as a continuous variable, divided into quartiles).

^cThe strength of evidence for each DMR is summarized with its area [18].

^dNA, not applicable, i.e. the CpG is not present in any known gene, the gene name in brackets denotes the gene with the closest transcription start site.