Table 6. Comparative studies evaluating capsular contracture (cc) rates (ADM versus Non-ADM).

Reference	Groups compared	Variables	Method of assessment	Follow-up period	Results
Vardanian et al [30], 2011	ADM (Alloderm) n = 208 Non-ADM – partial (n = 119) and total (n = 10) sub-muscular	No significant difference (NSD) between cohorts in terms of age, BMI, smoking and indication for reconstruction	Retrospective chart review of recorded Baker score. Considered significant if Baker III or IV	Median 29 months post-implant exchange for both cohorts – not compared. Range not reported	Overall cc rates: ADM 3.8%; non-ADM 19.4% p < 0.001. On multivariate analysis ADM use associated with significantly lower cc rates (OR 0.18; 95% CI 0.08–0.43)
Forsberg et al [29], 2014	ADM (type not specified) n = 58 Non-ADM n = 125	NSD between cohorts in terms of age, BMI, smoking, diabetes, adjuvant therapy, implant type (saline/silicone) or size. Significant difference in the number of immediate reconstructions (higher in ADM cohort) and length of follow-up period	Retrospective chart review of recorded Baker score. Considered significant if Baker III or IV	ADM 24.6 months Non-ADM 33.8 months p = 0.005	Significant difference in cc rates: ADM: 8.1% Non-ADM 23.5% P = 0.048