Table 2.

Differences between CC-CLIA and CC-SCV

	CC-CLIA	CC-SCV
Occurrence	CV-PTC > con-PTC	Con-PTC
Distribution	Focal	Focal
Location	Papillae with cystic change	Papillae with cystic change
Cell shape	Tall columnar	Hobnail
Cytoplasm	Pale, foamy	Dense, multivacuolated
Vacuoles
Location	Subnuclear (basal)	Supranuclear (apical)
Border	Obscure	Clear
Lipid (oil red O stain)	Positive	Positive
Adipophilin	Positive	Positive

CC-CLIA, carcinoma cells with cytoplasmic lipid accumulation; CC-SCV, carcinoma cells with septate cytoplasmic vacuoles; CV-PTC, cribriform variant of papillary thyroid carcinoma; con-PTC, conventional papillary thyroid carcinoma.