Fig. 3.

a The high-fat diet caused a progressive reduction in the sensitivity of aortic rings to the vasodilator cromakalim and this reached significance after 4 months of diet. *** p < 0.001 vs. the C57BL/6⁻ control group. b In C57BL/6 mice, vasodilation in response to the AMPK activating agent A769662 was attenuated by the IP3 receptor antagonist xestospongin C (5 µM). *** p < 0.001 vs. the C57BL/6 control group. c In ApoE^−/− mice on the diet for 4 months, relaxation to A769662 was also significantly reduced by 5 µM xestospongin C. * p < 0.05 vs. the ApoE^−/− control group. n > 3 for all groups. 2m, 2 months of high-fat feeding; 4 m, 4 months of high-fat feeding.