Fig. 1.

Study schema for without-food and with-food dosing. ↑, scheduled blood draw; B, baseline; F1, follow-up; F2, follow-up visit 2; HK, hyperkalemia; QD, once daily; R, randomized; * At the baseline visit (day 1), patients remained fasted from the evening before and blood samples were obtained immediately prior to the initial 8.4 g dose of patiromer (baseline/hour 0); patients were provided with a light meal after the 1-h blood draw. Starting day 2, patients began the starting dose of 8.4 g patiromer QD with food or without food based on their assigned treatment group.