Table 2.
Respiratory outcomes
| Intervention group (N=24) | Standard management (N=21) | P value* | |
|---|---|---|---|
| Age at surfactant administration, hours† | 15.4 (6.0–20.4) | 7.2 (4.8–17.5) | 0.26 |
| Number of surfactant doses per patient, mean (SD) | 1.5 (1.2–1.9) | 1.2 (0,88–1.40) | 0.11 |
| One surfactant dose, N (%) | 15 (62.5%) | 14 (66.7%) | 1.00 |
| Two or more surfactant doses, N (%) | 9 (37.5%) | 5 (23.8%) | 0.35 |
| Duration of NIV, days† | 4.2 (2.8–5.4) | 3.6 (2.3–4.9) | 0.56 |
| Duration of MV, days†,‡ | 2.9 (1.2–4.0) | 1.9 (0.8–3.2) | 0.27 |
| Duration of ventilation (NIV + MV), days† | 4.5 (3.4–6.7) | 6.3 (3.7–7.1) | 0.26 |
| Duration of oxygen administration, days† | 2.4 (1.9–2.8) | 2.3 (0.3–3.6) | 0.63 |
| Duration of NICU hospitalization, days† | 12.8 (7.0–20.1) | 16.2 (7.6–34.3) | 0.18 |
N Numbers; NICU Neonatal intensive care unit; NIV Noninvasive ventilation; MV Mechanical ventilation; SD Standard deviation.*Based on an exact Pearson chi-square test or Wilcoxon Mann–Whitney test. †Results presented as median with interquartile range. ‡Included 7 patients exposed to MV in the intervention group and 18 patients in the control group.