Table 5.
Cell Signaling Proteins in Amoebozoa Genomes
| Category | Protostelium aurantium | Dictyostelium discoideum | Physarum polycephalum | Acanthamoeba castellanii |
|---|---|---|---|---|
| G-protein coupled receptors | 17 | 55 | 146 | 35 |
| Heterotrimeric G-proteins | ||||
| Alpha | 9 | 12 | 26 | 6 |
| Beta | 1 | 1 | 1 | n.d. |
| Gamma | 1 | 1 | 1 | n.d. |
| Histidine kinases/phosphatases | 71 | 16 | 51 | 48 |
| Cyclic nucleotide signaling | ||||
| Adenylate/guanylate cyclases | 52 | 5 | 64 | 67 |
| cNMP binding domains | 27 | 5 | 28 | 7 |
| cNMP phosphodiesterases | 16 | 7 | 11 | 10 |
| Protein kinases | ||||
| All (S/T, S/T/Y, Y) | 827 | 295 | 447 | 377 |
| Sensor tyrosine kinases (Y) | 167 | 0 | 4 | 21 |
| SH2 domain proteins | 85 | 15 | 18 | 48 |