Figure 1.

Early and late treatment with the antidepressants desipramine, duloxetine, and fluoxetine. The mechanical threshold was evaluated using von Frey hairs, data are represented as mean ± SEM, and n are expressed between brackets. Early 15-day treatments starting 1 h prior to the surgery with desipramine (desip 5 mg/kg i.p. twice a day) (a), duloxetine (dulox 10 mg/kg i.p. twice a day) (c), or fluoxetine (fluox 10 mg/kg i.p. twice a day) (e) had no effect on allodynia. Later treatments, starting 25 days after surgery, with desipramine (b) or duloxetine (d) relieved allodynia, and a relapse was observed after treatment interruption; while the treatment with fluoxetine (f) had no effect on cuff-induced allodynia. PWT: paw withdrawal threshold.