Figure 2.

Early and late treatments with the anticonvulsants gabapentin and carbamazepine. The mechanical threshold was evaluated using von Frey hairs, data are represented as mean ± SEM, and n are expressed between brackets. Early 10-day treatments with gabapentin (gaba 10 mg/kg s.c. twice a day) (a) or carbamazepine (carba 40 mg/kg s.c. twice a day) (c) did not affect the mechanical thresholds after surgery. After the end of the treatments, a progressive recovery from allodynia was observed for both anticonvulsants. Later treatments, starting 25 days after surgery, with gabapentin (gaba 10 mg/kg s.c. twice a day) (b) or carbamazepine (carba 40 mg/kg s.c. twice a day) (d) relieved allodynia, and a relapse was observed after treatment interruption. PWT: paw withdrawal threshold.