Figure 3.

Early and late treatments with ketamine and dexamethasone. The mechanical threshold was evaluated using von Frey hairs, data are represented as mean ± SEM, and n are expressed between brackets. Early ketamine treatment (keta 15 mg/kg i.p. twice a day) progressively relieved neuropathic allodynia, with a relapse of allodynia slowly reappearing over two months (a). Late ketamine treatment led to a partial recovery, and a relapse was observed after treatment interruption (b). Early dexamethasone treatment (dexa 2 mg/kg s.c. once a day) did not significantly affect the mechanical thresholds after the surgery (c). Late dexamethasone treatment alleviated the allodynia, and a relapse was observed after treatment interruption (d). PWT: paw withdrawal threshold.