Figure 4.

Conceptual illustration of early and late treatment impact on mechanical allodynia. The allodynia measured following sciatic nerve compression (a) may be the result of two distinct allodynia mechanisms (b). Early treatments preventing allodynia chronification may block the induction of late allodynia without affecting the early allodynia and have long-lasting consequences (c). Classical treatments in a more chronic stage of neuropathic pain would temporarily alleviate late allodynia (d).