Table 1.

Selected studies on the perisurgical preventive treatment of pain.

Ref.	Species	Pain disorder	Treatment	Duration	Efficacy
Amr 2010 15	Human	Breast cancer surgery	Gabapentin 300mg	Before and 10 days postop	No at month 6
Brogly 2008 16	Human	Thyroidectomy	Gabapentin 1200mg	2h before	Yes at month 6
Clarke 2009 17	Human	Hip arthroplasty	Gabapentin 600mg	2h before	No at month 6
Fassoulaki 2002 18	Human	Breast cancer surgery	Gabapentin 1200mg	Before and 10 days postop	No at month 3
Fassoulaki 2005 19	Human	Breast cancer surgery	Gabapentin 1600mg + local anesthetics	Before and 8 days postop	Yes at month 3
					No at month 6
Moore 2011 49	Human	Caesarian delivery	Gabapentin 600mg	2h before	No at month 3
Sen 2009 20	Human	Hysterectomy	Gabapentin 1200mg	1h before	Yes at month1,3 and 6
Sen 2009 21	Human	Inguinal herniorraphy	Gabapentin 1200mg	1h before	Yes at month1,3 and 6
Camara 2015 24	Rat	Chronic constriction sciatic nerve	Gabapentin oral 30, 60, 120 mg/kg	1h before and 15 days along	Yes at 5 and 15 days (60min after administration)
Burke 2010 22	Human	Lumbar discectomy	Pregabalin 300mg	Before and 150mg at 12 and 24h postop	Yes at 3 months
Buvanendran 2010 52	Human	Knee arthroplasty	Pregabalin 300mg	Before and 50-150mg 14 days postop	Yes at 6 months
Pesonen 2011 23	Human	Cardiac surgery	Pregabalin 150mg	Before and 5 days postop	Yes at 3 months
Matsutani 2015 51	Human	Thoracotomy	Pregabalin 75mg	Before and 150mg 14 days postop	Yes at 1, 2 and 3 months
Li 2007 25	Rat	Sciatic nerve ligation	Corticosteroid triamcinolone s.c. 1.5mg/kg	1h before and 3 days	Yes 7 days after surgery
Bergeron 2009 31	Human	Hip arthroplasty	Corticosteroid dexamethasone IV 40mg	One preoperative dose	No at 6 weeks and 1 year
Romundstad 2004 28	Human	Orthopaedic surgery	Corticosteroid methylprednisolone IV 125mg	1 day after surgery	Yes at 24h after infusion
De Kock 2001 10	Human	Resection of rectal cancer	Ketamine IV 0.5mk/kg bolus and infusion 0.25mg/kg/h	30min before and during surgery	Yes at 2 weeks, 1 and 6 months, 1year
Loftus 2010 11	Human	Major lumbar spine surgery	Ketamine IV 0.5mk/kg bolus and 10µg/kg/min	Before and during surgery	Yes at 6 weeks
Sun 2014 32	Rat	Plantar incision	Duloxetine IP 20 or 40mg/kg	24h after incision	Yes 120min after administration
Hajhashemi 2014 33	Rat	Chronic constriction injury (CCI)	Venlafaxine IP 10 and 20mg/kg	Day 1 after CCI and daily until day 14	Yes at days 7, 10, 14 after CCI
			Venlafaxine IP 20mg/kg	Day 10 after CCI until day 21	No
Ho 2010 38	Human	Knee replacement	Duloxetine 60mg orally	2h before and day 1	No at months 3 and 6
Chocron 2013 39	Human	Coronary artery bypass grafting	Escitalopram 10mg orally	2-3 weeks before and 6 months postop	No at months 1, 3 and 6
Amr 2010 15	Human	Breast cancer surgery	Venlafaxine 37.5mg orally	before and 10 days postop	Yes at 6 months on burning and stabbing pain No on pain at rest