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. Author manuscript; available in PMC: 2018 Feb 8.
Published in final edited form as: Vaccine. 2015 Mar 13;33(18):2152–2158. doi: 10.1016/j.vaccine.2015.03.009

Fig. 2.

Fig. 2

Morbidity of VLP vaccinated ferrets following Anhui/1 virus challenge. Ferrets (6 per group) received two intramuscular inoculations (4 weeks apart) in the presence or absence of ISCOMATRIX adjuvant and control animals received PBS in place of vaccine. Following H7N9 virus challenge ferrets were weighed daily to measure morbidity. Average weights in each vaccine group were measured for the duration of the study, and percent original body weight was calculated based on the average starting weight for each group on day 0. Statistical significance from PBS group was determined by analysis of area under curve (AUC) with ANOVA and Bonferroni post-test; p < 0.05 for VLP versus PBS, p < 0.001 for VLP + ISCO versus PBS group.