Table 1.
Geometric mean of neutralizing (neut) and hemagglutination inhibition (HI) serum antibody titers following H7N9 VLP inoculation in ferrets.a
| Vaccine group | Neut titerb | HI titerb | ||
|---|---|---|---|---|
|
|
|
|||
| Pre-boost | Pre-challenge | Pre-boost | Pre-challenge | |
| Experiment 1 | ||||
| VLP | 16 (10–20) | 113 (80–160) | 9 (5–10) | 80 (80) |
| VLP + ISCOMATRIX | 63 (40–80) | 254 (160–320) | 35 (20–40) | 142 (80–160) |
| PBS | <10 | <10 | <10 | <10 |
| Experiment 2 | ||||
| VLP | 20 (10–20) | 101 (80–160) | 7 (5–10) | 63 (40–80) |
| VLP + M1 | 50 (40–80) | 285 (160–320) | 25 (20–40) | 202 (160–320) |
| PBS | <10 | <10 | <10 | <10 |
a
Ferrets were vaccinated i.m. two times with the 15 μg of H7N9 VLP.
b
Samples were tested for HI and neutralization antibody activity against A/Anhui/1/2013 virus. Geometric mean titers (with range in parentheses) are shown as the reciprocal of the highest dilution of serum that completely inhibits HI or that neutralized 100 pfu of infectious virus (neut).