Table 2.
Vaccine groupa | Clinical symptoms of H7N9 challenged ferrets | ||
---|---|---|---|
| |||
Mean temp increase over baseline (3C)b | Mean % weight lossc | Mean peak viral titerd | |
VLP | 2.0 | 7.4 | 5.0 ± 0.18 |
VLP + ISCOMATRIX | 1.3 | 3.5 | 4.2 ± 0.04 |
PBS | 2.3 | 12.7 | 6.5 ± 0.11 |
Ferrets were vaccinated i.m. two times with the 15 μg of H7N9 VLP.
Temperature increases over ferret baseline of 38.5 ± 0.2 °C, all maximum temperatures from day 2 p.c.
Mean maximum weight loss percentage values shown (day 7 or 8 post-challenge) for 6 ferrets per group.
Virus detected in nasal wash samples, mean peak titer shown as log10 pfu/ml including standard deviation. All peak titers from day 2 p.c.