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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J Comp Neurol. 2017 Jun 29;525(16):3391–3413. doi: 10.1002/cne.24259

FIGURE 1.

FIGURE 1

Stem and progenitor progression in the neuronal lineage. Horizontal basal cells (HBCs) are K5 (+) multipotent progenitors (MPPs) able to give rise to all cell types of the OE following activation. The GBC population can be subdivided into stages of progenitor capacity (Schwob et al., 2017): GBCs that function as MPP express Sox2 and Pax6; GBCs that function as transit-amplifying neuronally committed cells (TA-N) express Ascl1; GBCs that function as immediate neuronal precursors (INP) express Neurog1. Immature OSNs express GAP-43 and mature OSNs express OMP. This study used CreERT2 drivers to conditionally delete Lsd1 in K5 (+) HBCsMPP., Ascl1 (+) GBCsTA-N and Neurog1 (+) GBCsINP