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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J Comp Neurol. 2017 Jun 29;525(16):3391–3413. doi: 10.1002/cne.24259

FIGURE 8.

FIGURE 8

Neuronal maturation is halted in activated HBCs lacking LSD1. (a, b) Transgenic mice and experimental design. (c–f) Activated HBCMPPs from Lsd1+/+ and Lsd1fl/+ mice mature into OMP (+) OSNs by 3 weeks post-MeBr lesion. (d, f) are taken from sections adjacent to (c), (e), respectively. (g–h) Activated HBCMPPs from Lsd1fl/fl mice are unable to mature into OMP (+) OSNs and instead halt in maturation as Tuj1 (+) immature OSNs. H is taken from a section adjacent to (g). (i) Quantitation of the percent of activated HBCs that are OMP (+) cells out of the total number of counted lineage-traced neurons (OMP (+) and Tuj1 (+) OSNs inclusive). Mean percent and SEM are plotted for each genotype (n = 3 per genotype). Dotted white line indicates the basal lamina, scale bar in (h) equals 20 μm and applies to (c–g) as well while scale bar in inset (f) represents 20 μm and applies to insets (e1), (e2), and (f). Scale bar in (h1) represents 20 μm and applies to insets (c1.1–h1)