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. 2018 Feb 8;13(2):e0191523. doi: 10.1371/journal.pone.0191523

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© 2018 Jaudan et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — P_N elevates Apoptosis and DNA damage: (A) Representative dot-plot of flow-cytometric analysis of P_N treated, vehicle treated and D_X treated HeLa cells labeled with PI and analyzed by FCS Express.v5 software. (B) Representative dot-plot of flow-cytometric analysis of P_N treated, vehicle treated and D_X treated HeLa cells labeled with AnnexinV-FITC and analyzed by FCS Express.v5 software. (C) Changes in mean fluorescence intensity (PI) after P_N treatment in HeLa cells. (D) Changes in mean fluorescence intensity (AnnexinV-FITC) after P_N treatment in HeLa cells. Ordinary one-way ANOVA (Dunnett's multiple comparisons test) was performed to calculate the statistical difference (p≤0.05) among all treated groups as compared to vehicle treated group. (E) Changes in apoptotic unit (%) were measured via tunnel assay on incubating P_N treated HeLa cells with Caspase 3 inhibitor (Z-DEVD-FMK-Caspase-3. Student t-test (two-tailed, paired) was performed to calculate the statistical difference (p≤0.002) among all treated groups as compared to vehicle treated group. P_N: Pinostrobin, D_X: Doxorubicin, VC: Vehicle control. *, p≤0.05; **, p≤0.01; ***, p≤0.005; ****, p≤0.001.