Fig 5. Integrin-expressing CD4⁺ and CD4^negT cell densities in the blood, cervix and rectum.

(A) CD4^neg:CD4⁺ ratio of all CD3⁺cells expressing α4^-β7^-, αE⁺β7^hi, α4⁺β7^hi, α4^intβ7^int or α4⁺β1⁺ in blood, cervix and rectum. (B) The densities of αE⁺β7^hi, α4⁺β7^hi and α4⁺β1⁺T cells in this pie charts were drawn based on integrin-expressing T cells in each tissue and does not account for the total density of T cells in each site. Data from 45 female subjects presented as median (IQR). *P < 0.05 **P < 0.01 ***P < 0.001 ****P < 0.0001, as calculated by Friedman Test, followed by Wilcoxon signed rank-test, and adjusted for multiple comparisons using step-down procedure.