Model 1			Model 2
	Mean Diff.	95% CI	p value	Mean Diff.	95% CI	p value
Year of ART Initiation			<0.001			<0.001
2003–2005	ref			ref
2006–2009	6	(2, 10)	0.001	7	(3, 11)	0.001
2010–2013	9	(5, 13)	<0.001	11	(7, 15)	<0.001
Time from ART initiation (per month)	16	(15, 16)	<0.001	16	(15, 16)	<0.001
Age at ART initiation (years)			<0.001
≤30	ref			ref
31–40	−5	(−8, −2)	0.003	−5	(− −9, −2)	0.001
41–50	−11	(−15, −7)	<0.001	−12	(−16, −8)	<0.001
51+	−7	(−12, −2)	0.004	−8	(−13, −3)	0.001
Sex
Male	ref			ref
Female	1	(−2, 4)	0.445	1	(−2, 5)	0.332
Mode of HIV Exposure			<0.001			<0.001
Heterosexual contact	ref			ref
Homosexual contact	11	(5, 16)	<0.001	11	(6, 16)	<0.001
Injecting drug use	−17	(−24, −10)	<0.001	−17	(−24, −10)	<0.001
Other/unknown	4	(−1, 9)	0.111	4	(−1, 9)	0.111
Pre-ART CD4 cell count (cells/μL)
≤50				ref
51–100				11	(7, 16)	0.000
101–200				9	(5, 13)	0.000
201+				−3	(−6, 1)	0.169
First ART regimen			0.009			0.013
NRTI1+NNRTI2	ref			ref
NRTI1+PI3	−4	(−10, 3)	0.263	−3	(−9, 3)	0.374
Other/unknown	20	(6, 35)	0.007	20	(5, 35)	0.007

Note: Global p-values for year of ART initiation, pre-ART CD4 count and age are test for trend. Other global p-values are test for heterogeneity.

¹NRTI = nucleoside reverse transcriptase inhibitor.

²NNRTI = nonnucleoside reverse transcriptase inhibitor.

³PI = protease inhibitor.