Table 2. Comparison of laboratory findings between iMCD and IgG4-RD.
| iMCD (n=22) |
IgG4-RD (n=26) |
p-value | |
|---|---|---|---|
| IgG | |||
| Concentrations (mg/dL)* | 4,782 (811-31,313) | 2,098 (1,150-4,661) | <0.001 |
| >1x ULN (n, %) | 19 (86%) | 20 (77%) | 0.478 |
| >2x ULN (n, %) | 16 (73%) | 5 (19%) | <0.001 |
| IgG4 | |||
| Concentrations (mg/dL)* | 483 (50-1,230) † | 611 (146-2,140) | 0.270 |
| >1x ULN (n, %) | 14 (88%)† | 26 (100%) | 0.139 |
| >2x ULN (n, %) | 12 (75%)† | 21 (81%) | 0.956 |
| IgG4/IgG ratio | |||
| Ratio (%) | 8.6 (1.5-23.6) † | 24.1 (8.7-59.0) | <0.001 |
| >5% (n, %) | 12 (75%)† | 26 (100%) | 0.016 |
| >10% (n, %) | 5 (31%)† | 25 (96%) | <0.001 |
| CRP | |||
| Concentrations (mg/dL)* | 6.7 (1-50.4) | 0.1 (0-1.25) | <0.001 |
| >1x ULN (n, %) | 22 (100%) | 5 (19%) | <0.001 |
| >5x ULN (n, %) | 20 (91%) | 0 | <0.001 |
| Hemoglobin (g/dL) | |||
| Concentration (g/dL)* | 9.9 (6.6-13.4) | 13.6 (9.6-15.5) | <0.001 |
| <1x LLN (n, %) | 21 (95%) | 10 (38%) | <0.001 |
| IL-6 (pg/mL) | |||
| Concentration (pg/mL)* | 21.6 (4-76)‡ | NA | NA |
| >1x ULN (n, %) | 19 (95%)‡ | NA | NA |
ULN, the upper limit of normal; LLN, the lower limit of normal; *, data are shown as a median (range); †, data available in 16 cases; ‡, data available in 20 cases. Normal ranges: IgG, 870-1,700 mg/dL; IgG4, <135 mg/dL; CRP, 0-0.3 mg/dL; hemoglobin, 11.8-15.0 g/dL (female), 13.6-17.0 g/dL (male); IL-6, 0-4 pg/mL.