Table 4. Comparison of lymph node pathology between iMCD and IgG4-RD.
| iMCD (n=14) |
IgG4-RD (n=10) |
p-value | |
|---|---|---|---|
| Findings in iMCD diagnostic criteria (n, %) | |||
| Regressed germinal centers (G2-3) | 4 (29%) | 1 (10%) | 0.358 |
| Follicular dendritic cell prominence (G2-3) | 4 (29%) | 3 (30%) | 1.000 |
| Vascularity (G2-3) | 11 (79%) | 6 (60%) | 0.393 |
| Hyperplastic germinal centers (G2-3) | 6 (43%) | 8 (80%) | 0.104 |
| Plasmacytosis (G2-3) | 12 (86%) | 7 (70%) | 0.615 |
| Plasmacytosis (G3) | 11 (79%) | 0 | <0.001 |
| Other findings (n, %) | |||
| Eosinophil infiltration (>10 cells/hpf) | 0 | 4 (40%) | 0.020 |
| Neutrophil infiltration (>10 cells/hpf) | 0 | 0 | |
| Broadened laminated mantle zone | 5 (36%) | 1 (10%) | 0.341 |
| Immunohistochemistry | |||
| IgG4+ plasma cells | |||
| Positive cell count (median, range) | 247.5 (4-636) | 236 (23-370) | 0.953 |
| >10 cells/hpf (n, %) | 13 (93%) | 10 (100%) | 1.000 |
| >50 cells/hpf (n, %) | 12 (86%) | 9 (90%) | 1.000 |
| IgG4+/IgG+ plasma cell ratio | |||
| Ratio (median, range) | 36.7 (2.1-71.5) | 68.3 (43.6-94.9) | 0.002 |
| >40% (n, %) | 5 (36%) | 10 (100%) | 0.002 |
| >70% (n, %) | 2 (14%) | 4 (40%) | 0.192 |
G2, grade 2; G3, grade 3.