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(A) Inhibition of PDX breast tumors by ZB716 orally administered to mice at 5 and 20 mg/kg, and by fulvestrant 200 mg/kg subcutaneously injected at 200 mg/kg weekly. (B) Downregulation of ERα in tumor tissues treated by fulvestrant, ZB716 5mg/kg, or ZB716 20 mg/kg, respectively.
