Table 1. No. of methylated promoter regions according to clinicopathological features.
| Patients, n (%) | Methylations, median (range) | P-value | |
|---|---|---|---|
| Total | 193(100) | 5(0-28) | |
| Age | |||
| ≤ 67 | 91(47.15) | 5(0-28) | |
| > 67 | 102(52.85) | 5(0-25) | 0.182 |
| Sex | |||
| Male | 119(61.66) | 4(0-28) | |
| Female | 74(38.34) | 5(0-26) | 0.228 |
| Smoke status | |||
| Never smoker | 68(35.23) | 5(0-25) | |
| Current smoker | 77(39.90) | 4(0-26) | |
| Previous smoker | 43(22.28) | 5(0-28) | |
| Unknown | 5(2.59) | 5(4-8) | |
| CEA-levels | |||
| ≤ 5 ng/ml | 141(73.06) | 5(0-20) | |
| > 5 ng/ml | 52(26.94) | 6(1-28) | 0.002 |
| Tumour | |||
| T1 | 3(1.55) | 5(4-5) | |
| T2 | 30(15.54) | 3.5(0-11) | |
| T3 | 120(62.18) | 5(2-26) | |
| T4 | 34(17.62) | 6(1-28) | 0.113 |
| T-unknown | 6(3.11) | 22(5-25) | |
| Node | |||
| N0 | 121 | (62.69) | 5(0-16) |
| N1 | 38(19.69) | 5(0-23) | |
| N2 | 28(14.51) | 5(1-28) | 0.231 |
| N-unknown | 6(3.11) | 22(5-25) | |
| Metastasis | |||
| M0 | 159(82.38) | 5(0-19) | |
| M1 | 34(17.62) | 9(0-28) | <0.001 |
The number (n) and percentages (%) of colorectal cancer patients according to their respective clinicopathological features and the tumour (T), node (N), and metastasis (M) system. The median number and range of methylated promoter regions (Methylations) are also presented with p-values according to the different clinicopathological features. TNM-staging was performed after surgery from the pathological sections. P-values are calculated using the Wilcoxon-Mann-Whitney test. The P-value for T-stage was calculated to distinguish T1/2 tumours from T3/4 tumours. The P-value for N-stage was calculated to distinguish N0 from N1/2 disease. The P-value for M-stage, was calculated to distinguish M0 from M1 disease.