Table 5. Haplotype analysis for genotypes of HLA-DP/DQ and IgAN risk.
Haplotypes | Case (freq.) | Control (freq.) | OR (95%CI) | p |
---|---|---|---|---|
AAA | 11.50 (0.041) | 50.15 (0.051) | 0.81 (0.42~1.56) | 0.526019 |
AAG | 64.41 (0.230) | 174.03 (0.178) | 1.42 (1.03~1.96) | 0.033938 |
AGG | 40.29 (0.144) | 95.49 (0.097) | 1.59 (1.07~2.36) | 0.020488 |
GAG | 73.31 (0.262) | 131.98 (0.135) | 2.34 (1.69~3.24) | 1.67E-07 |
GGA | 7.91 (0.028) | 58.67 (0.060) | 0.46 (0.22~0.99) | 0.041992 |
OR: odds ratio; CI: confidence interval; IgAN: IgA nephropathy.
Order of HLA haplotype block: rs3077 (minor allele A), rs9277535 (minor allele A) and rs7453920 (minor allele A).
Bold values are statistically significant (p < 0.05).