Table 1. Reported sensitivity and specificity of urine-based single protein biomarkers for the detection of bladder cancer.

Protein name	Sensitivity (%)	Specificity (%)	Cancer (n)	Control (n)	Ref.
Alpha-1-anti-trypsin	74	80	54	46	[32]
Alpha-1-anti-trypsin	71	72	102	206	[40]
Angiogenin	66	75	50	40	[41]
Apolipoprotein A1	95	92	49	37	[42]
Apolipoprotein A4	79	100	110	66	[18]
AMFR	84	75	45	62	[43]
BIGH3	93	80	30	15	[44]
Calprotectin	80	93	46	40	[45]
Cathepsin B	56	56	122	107	[46]
Cathepsin L	71	75	122	107	[46]
CCL18	70	68	102	206	[40]
CD147	97	100	30	15	[44]
CEACAM1	74	95	95	82	[47]
Clusterin	68	61	68	61	[48]
Clusterin	70	83	50	40	[41]
Coronin-1A	67	100	110	66	[18]
CXCL1	72	95	95	30	[49]
CXCL1	56	84	43	43	[50]
CYFRA21-1	79	89	82	70	[51]
CYFRA21-1	81	97	86	76	[52]
CYFRA21-1	70	43	125	321	[53]
CYFRA21-1	97	67	48	80	[54]
DJ1	83	100	110	66	[18]
EN2	82	75	466	55	[55]
FDP	52	91	57	139	[56]
Fibronectin	91	88	75	55	[57]
Fibronectin	72	82	126	41	[58]
Prothrombin	71	75	76	80	[17]
Reg-1	81	81	23	48	[59]
Semenogelin-2	67	80	110	66	[18]
Stathmin-1	90	87	30	15	[44]
Telomerase	70	99	57	139	[56]
Telomerase	83	89	73	37	[60]
g-synuclein	88	90	110	66	[18]