Table 3. Results from compartmental modeling and Logan graphical analysis of the PET data of the PBMC implant.
Xenograft TACs | Plasma TACs | |||||
---|---|---|---|---|---|---|
Parameter | VT (2TCM) | BPND (2TCM) | VT (Logan) | AUC | Half- life | |
T1 | T2 | |||||
Wild-type [18F]FB-IL2 | 0.40 ± 0.20 | 10.6 ± 2.9 | 0.47 ± 0.02 | 50.1 ± 3.7 | 0.7 ± 0.2 (17 %) | 7.1 ± 2.6 (83%) |
Mutant [18F]FB-IL2v | 0.18 ± 0.04 | 4.3 ± 0.5 | 0.21 ± 0.01 | 40.7 ± 1.9 | 2.1 ± 1.3 (14%) | 17.6 ± 1.3 (86%) |
p < 0.01 | p < 0.001 | p < 0.01 | p < 0.05 | NS | p < 0.01 | |
Mutant [18F]FB-IL2v + 5 mg/kg wild-type IL2 | 0.07 ± 0.02 | 2.2 ± 0.7 | 0.10 ± 0.01 | 31.7 ± 0.4 | 1.1 ± 0.6 (14%) | 38.2 ± 1.6 (86%) |
p < 0.001 | p < 0.001 | p < 0.001 | p < 0.05 | NS | p < 0.01 |
Bi-exponential clearance of the tracer was observed in plasma. The data represent the mean ± standard deviation.