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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Nat Genet. 2018 Jan 1;50(2):229–237. doi: 10.1038/s41588-017-0009-4

Fig. 2. Evaluation of MTAG’s standard errors when there is sample overlap.

Fig. 2

The x-axis is a SNP’s z-statistic from a baseline GWAS conducted in UK Biobank. The y-axis is a SNP’s z-statistic from applying MTAG to three GWASs of each trait conducted on equally sized subsamples of the baseline sample, in which every pair of samples has 50% overlap. (a) Height. (b) Depressive symptoms. The figure illustrates near-perfect alignment. See Supplementary Note for details and results from analogous analyses on additional phenotypes.